Uji Efek Teratogen Anti Nyamuk Bakar yang Mengandung Transfluthrin terhadap Fetus Mencit Putih

Almahdy Ahmadin, Dachriyanus Dachriyanus, Maryorie Rosa

Sari


Teratogenic test of anti-mosquito coils containing transfluthrin has been conducted on fetus of laboratory mice. Pregnant mice had been given anti-mosquito exposure by inhalation of anti-mosquito coils smoke during the period of organogenesis which begins from the sixth to the fifteenth day of pregnancy. Laparactomy was conducted on the eighteenth day of pregnancy, then two-thirds of the fetus is immersed in a solution of red-alizarin and the remaining in Bouin's solution. The results showed that the fetus with two times of exposure to anti-mosquito coils smoke leads to resorption tread and slower fetal growth. At three times of exposure, showing slower fetal growth, fatality when the laparactomi was conducted, haemorrhage and anencephaly. At four times of the exposure can cause slower fetal growth, fatality on laparactomy and haemorrhage. Exposure to anti-mosquito coils smoke can also lead to reducing weight of the mice and fetus significantly.


Teks Lengkap:

PDF

Referensi


Almahdy ., (2004). Uji Aktivitas Teratogenitas Ekstrak Etanol Daun Inggu (Ruta graveolens Linn.) pada Mencit Putih. Jurnal Sains dan Teknologi Farmasi. 82-87.

Almahdy., Arifin, H., Delvita, V. (2007). Pengaruh Pemberian Vitamin C terhadap Fetus pada Mencit Diabetes. Jurnal Sains dan Teknologi Farmasi. 12(1). 32-40.

Almahdy. (2010). Pengaruh Ekstrak Gambir (Uncaria gambier Roxb.) terhadap Fetus dari Mencit Hamil yang Diinduksi Alkohol, Majalah Farmasi Indonesia. 21(2). 115-120.

Almahdy., Marusin, N., Fitri, H. (2011). Uji Aktivitas Vitamin A terhadap Efek Teratogen Warfarin pada Fetus Mencit Putih, disampaikan pada Prosiding Seminar Nasional Biologi Dept. Biologi FMIPA USU. Medan: USU Press.

Harbinson, R. D. (2001). The Basic Science of Poison in Cassaret and Doull’s Toxicology. New York: Macmillan Publishing Co. Inc.

Hayes, A. Wallace. (2001). Principles and Methods of Toxicology. (Edisi Keempat). USA: Taylor & Francis Routledge.

Liu, W., Zhang, J., Hashim, J.H., Jalaludin, J., ¬¬Hashim, Z., & Goldstein, B.D. (2003). “Mosquito Coil Emissions and Health Implications”. Environment Health Perspective, 111(2), 1454-1460.

Lu, F.C. (1995). Basic Toxicology (Edisi kedua). Penerjemah: E. Nugroho. Chicago: University of Chicago Press.

Marjuki, M. I. (2009). Daya bunuh beberapa obat nyamuk bakar terhadap kematian nyamuk Anopheles aconitus. (skripsi). Surakarta : Fakultas farmasi UMS.

Manson, J.M. (1986). The Basic Science of Poisons in Casarett and Doull’s Toxicology. New York : MC Millan Publishing Co.

Okine, L.K.N., Nyarko, A.K., Armah, G.E., Awumbila, B., Owusu, K., Setsoavia, S., Ofosuhene, M. (2004). Adverse Effects of Mosquito Coil Smoke on Lung, Liver and Certain Drug Metabilishing Enzymes in Male Wistar Albino Rats, Ghana Medical Journal, 38(3), 89-95.

Roberts, S.J. (1971). Veterinary Obstetrict and Genital Diseases (Therioge- nology). Ithaca. New York.

Triharso. (1994). Dasar - Dasar Perlindungan Tanaman. Yogyakarta: Fakultas pertanian UGM.




DOI: http://dx.doi.org/10.36434/scientia.v4i2.1

Refbacks

  • Saat ini tidak ada refbacks.


SCIENTIA Jurnal Farmasi dan Kesehatan

diterbitkan oleh STIFI Perintis Padang

Jl. Adinegoro km 17/Simp. Kalumpang Lubuk Buaya Padang – 25173

Telp. (0751) 482171  Fax. (0751)484522

    p-ISSN : 2087-5045                 e-ISSN : 2502-1834

       

 
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.